內容介紹
我和太太艾瑪出嚴重車禍,當我被固定在擔架上送往醫院,心中只想著,還好艾瑪是女生,有兩條X染色體。
前幾天Karen在整理到期合約時,發現這本強調女性基因上優勢的科普書,竟然到目前為止都還沒有中文版問世!快速閱覽書稿第一章,便欲罷不能地看下去。我不是生物學背景,但作者藉自身、臨床研究與經驗,並舉例蜜蜂的生態,以淺顯易懂的文字和令人莞爾的內心話,破解女性是弱勢性別的迷思,是一本老少咸宜的讀物。
每100位女新生兒對應105位男新生兒,讓科學家以為男性是強勢性別。事實上,只是因為女孩胚胎發育更為困難。1961年英國遺傳學家瑪莉·里昂(Mary F. Lyon)提出雌性個體細胞內僅含一條有活性的X染色體,在胚胎發育過程中會隨機去活化一條染色體,這個機制十分複雜,如果去活化不完全,胚胎就會流產。
後來的科學家更進一步發現,失活的染色體上仍有30%的基因保有活性,在女性碰到困難,如生病、老化、挨餓,細胞會去選擇當下對個體最有利的基因,助女性生存。因此,如飽受相同疾病所苦,女性的存活率會比男性更高。這樣的雌雄差異大大改變學界看待兩性臨床表現。僅使用雄性白老鼠的藥物開發實驗室,必然要改變現狀,將女性變數納入數據。
屢獲殊榮的醫師/科學家提出顛覆性的論點:基因上,女性在人生每個階段都比男性更強大!
以下是一些有趣的事實:
女性比男性長壽。100歲人瑞男女比2:8,110歲以上有95%是女性。
女性擁有更強的免疫系統,在對抗癌症和度過饑荒時表現更出色。
女性能看到更多顏色。
X染色體上有1,000多個基因;Y染色體上卻只有70個。
為什麼會這樣?
為了探究真相,作者回顧了自己的醫療經歷,試圖理解為何在每個案例中,男性始終較難存活。他發現,答案在於我們的基因:兩條X染色體提供了更強大的生存優勢。
作者以清晰、引人入勝的文字,交織令人震驚的研究、案例分析,以及從蜜蜂行為到美國拓荒者的多元例子,結合他個人生活與患者的經歷,解釋為什麼基因上,女性在韌性、智力、壽命、免疫力等方面超越男性。他還呼籲重新審視以男性為中心的醫學研究觀點,包括我們開藥的方式。
這本書既具革命性又令人信服,將讓你重新看待人類以及我們物種的生存。
作者介紹

醫學博士、科學家,暨《紐約時報》暢銷書作家。他是遺傳學及罕見遺傳病領域的世界知名專家,其臨床研究促成了兩種新型罕見遺傳病的發現。曾任《阿茲海默疾病期刊》的副主編,並與他人共同創辦了兩家生技公司。
他擁有超過25項與人類健康和生物技術相關的專利。他發現了一種全新的抗生素化合物,針對由抗甲氧苯青黴素金黃色葡萄球菌(MRSA)等超級細菌引起的感染,提供了藥物短缺的解方。
他的作品結合進化論、遺傳學、生物學與醫學。他是《紐約時報》暢銷書《病者生存:為何我們需要疾病?一位美國怪咖醫生顛覆你對疾病的看法!》(遠流)的作者,其他著作包括《遺傳密碼:我們不是被動的基因繼承者,童年創傷、飲食及生活習慣的改變,都能改變基因體的表現》(大塊)以及《妳有更多選擇權: 女性的基因優勢》等。他的書已被翻譯成超過35種語言。
書評
"Although Dr. Moalem had me at the subtitle, I tore through this fascinating, eye-opening book in one sitting. Provocative, crackling with wit and insight, THE BETTER HALF argues that science has shortchanged women in all levels of research and convincingly reveals that the true differences between men and women come down to longevity, intellect, resilience, and immunity to disease. Now it all makes sense why 95 percent of people who have reached the age of 110 are women." ―Jancee Dunn, New York Times–bestselling author of How Not to Hate Your Husband After Kids
"Let’s hear it for the X-chromosome! After decades, if not centuries, of bad press for women and their vulnerable biology, The Better Half gives chapter and verse to show that 'almost everything that is biologically difficult to do in life is done better by females.' An eye- and mind-opening celebration of the reserve genetic horsepower that having two X-chromosomes can bestow, The Better Half is a powerful antidote to the myth of a ‘weaker sex.'" ―Gina Rippon, PhD, author of The Gendered Brain and Professor Emeritus of Cognitive Neuroimaging at Aston University, Birmingham
This book provides the crucial scientific reasoning behind why it is essential to include males and females, both in people and animals, in order to get accurate results in medical research. ―Temple Grandin, PhD, New York Times–bestselling author of The Autistic Brain and Thinking in Pictures
"Moalem brings deep yet highly readable scientific analysis to the perennial question of what makes men and women different. Ideally, this book will re-set that conversation at research labs, doctors' offices, classrooms, and dinner tables around the world." ―E. Kinney Zalesne, New York Times–bestselling collaborator on Microtrends: The Small Forces Behind Tomorrow's Big Changes
"In The Better Half, Sharon Moalem presents his compelling argument for the resilience seen in women. But the real genius is the poetic justice he metes out by highlighting the brilliant women who remain unsung heroes in these discoveries." ―William J. Sullivan, PhD, Showalter Professor of Pharmacology & Toxicology, Microbiology & Immunology at Indiana University School of Medicine and author of Pleased to Meet Me
"The Better Half explores the genetic differences between males and females in a way that is both original and scientifically compelling. This book provides a great read, and lots to think about, for specialists and the public alike." ―Han G. Brunner, MD, PhD, Professor of Human Genetics at Radboud University Nijmegen Medical Center and Maastricht University Medical Center, the Netherlands
得獎紀錄
入圍 PEN / E. O. Wilson 科學寫作獎
相關連結
